Microbiome in the hair follicle of androgenetic alopecia patients

• DOI: 10.1371/journal.pone.0216330
• Publication Date: 2019-05-03T17:26:45Z
• Authors: Bryan Siu-Yin Ho; Eliza Xin Pei Ho; Collins Wenhan Chu; Srinivas Ramasamy; Mei Bigliardi-Qi; Paola Florez de S...; Paul Lorenz Bigli...
• Keywords: Cabello

Androgenetic alopecia is the most common form of hair loss in males. It a multifactorial condition involving genetic predisposition and hormonal changes. The role microflora during remains to be understood. We therefore analyzed microbiome follicles from patients healthy. Hair were extracted occipital vertex region healthy volunteers further dissected into middle lower compartments. was then characterized by 16S rRNA sequencing. Distinct microbial population found compartment follicles. Middle predominated Burkholderia spp. less diverse; while higher bacterial diversity observed portion. Occipital did not show significant differences. In patients, miniaturized houses elevated Propionibacterium acnes compartments non-miniaturized other regions comparable Increased abundance P. could associated immune response gene expression follicle.