Association between vitamin D and risk of cardiovascular disease in Chinese rural population

• DOI: 10.1371/journal.pone.0217311
• Publication Date: 2019-05-23T14:44:52Z
• Authors: Teng Wang; Hualei Sun; Huina Ge; Xinxin Liu; Fei Yu; Han Han; Jun Wang; Wenjie Li
• Keywords: Male; Rural Population; China; Science; Q; R; Comorbidity; Middle Aged; Vitamin D Deficiency; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Nonlinear Dynamics; Cardiovascular Diseases; Risk Factors; Prevalence; Medicine; Humans; Female; Vitamin D; Research Article; Aged

Previous studies have suggested that vitamin D is associated with cardiovascular disease (CVD), however, the relationship between levels and CVD risk still unclear. The purpose of this study was to assess serum concentration 25-hydroxyvitamin (25(OH)D) in rural residents Henan province China. Basic information medical history were gathered through face-to-face surveys from July 2013 August 2015, biochemical indicators a laboratory setting. Logistic restricted cubic splines regression analyses used estimate odd ratios (ORs) 95% confidence intervals (95%CI) CVD. A total 1078 participants included, mean 25(OH)D determined be 25 ± 18 ng/ml, 54.45% presenting deficiency [25(OH)D < 20 ng/mL]. Moreover, prevalence 59.28% deficient group, which higher than insufficient (48.55%) sufficient groups (52.78%). After adjusting for potential confounders, compared ORs CVDs 0.68 (0.50, 0.91) group 0.81 (0.56, 1.16) group. nonlinear (U-shaped) association observed concentration. Further research males females. In conclusion, U-shape identified our study, suggesting