Racial differences and mortality risk in patients with heart failure and hyponatremia

• DOI: 10.1371/journal.pone.0218504
• Publication Date: 2019-06-19T17:34:29Z
• Authors: Jeremy A. Miles; Renato Quispe; Yonatan Mehlman; Kavisha Patel; Claudia Lama Von ...; Jee Young You; Seth Sokol; Robert T. Faillace
• Keywords: Heart Failure; Peripheral Vascular Diseases; Science; Q; R; Myocardial Infarction; Comorbidity; Hispanic or Latino; Middle Aged; White People; 3. Good health; Black or African American; Hospitalization; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Atrial Fibrillation; Medicine; Humans; Female; Research Article; Aged; Hyponatremia; Retrospective Studies

Background Hyponatremia is a well-established poor prognostic marker in patients with heart failure. Whether the mortality risk comparable among different races of failure and hyponatremia unknown. Materials methods Consecutive admitted acute decompensated an admission sodium level<135 mEq/L from 1/1/2001 through 12/31/10 were identified. Patients divided into four groups based on self-reported race: white, African American, Hispanic other. Americans used as reference group for statistical analysis. The primary outcome was all-cause mortality. Results We included 4,343 patients, which 1,356 (31%) identified 1,248 (29%) 780 (18%) 959 (22%) During median follow-up 23 months, total 2,384 died: 678 820 298 588 After adjusting baseline demographics, comorbidities medication use, had 45% less death compared to (HR .55, CI .48-.64, p<0.05). There no difference between white American 1.04, .92–1.2, p = 0.79). Conclusion who hyponatremic independent lower other groups. These findings may be due disparate activity renin-angiotensin-aldosterone system various racial This observational study hypothesis generating suggests that treatment should perhaps focused more reduction certain groups, yet others.