An optimal condition for the evaluation of human brown adipose tissue by infrared thermography

• DOI: 10.1371/journal.pone.0220574
• Publication Date: 2019-08-26T17:28:56Z
• Authors: Shinsuke Nirengi; Hitoshi Wakabayashi; Mami Matsushita; Masayuki Domichi; Shinichi Suzuki; Shin Sukino; Akiko Suganuma; Yaeko Kawaguchi; Takeshi Hashimoto; Masayuki Saito; Naoki Sakane
• Keywords: Thermography; Skin Temperature

Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis and an attractive therapeutic target combating obesity related diseases. Human BAT activity has been evaluated by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18FDG-PET/CT) under acute cold exposure, but the method some serious limitations, including radiation exposure. Infrared thermography (IRT) may be a simple less-invasive alternative to evaluate activity. In present study, establish optimal condition IRT, using thermal imaging camera, skin temperature was measured in supraclavicular region close depots (Tscv) control chest (Tc) 24 young healthy volunteers. Their assessed as maximal standardized uptake value (SUVmax) 18FDG-PET/CT. Under warm at 24–27°C, no significant correlation found between IRT parameters (Tscv, Tc,, difference Tscv Δtemp) SUVmax, 30–120 min after exposure 19°C, Δtemp were significantly correlated with SUVmax (r = 0.40–0.48 r 0.68–0.76). not affected mean body temperature, fatness, blood flow. A lower 0.43) of also obtained when participant's hands immersed water 18°C 5 min. Receiver operating characteristic analysis revealed that 30–60 can used index evaluation 74% sensitivity, 92% specificity, 79% diagnostic accuracy. Thus, useful evaluating BAT, particularly large-scale screening longitudinal repeat studies.