Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium

• DOI: 10.1371/journal.pone.0224776
• Publication Date: 2020-02-20T13:28:36Z
• Authors: Duy Vuong Nguyen; Thomas Roret; Antonio Fernandez...; Annegret Kohler; Mélanie Morel-Rou...; Eric Gelhaye; Rodnay Sormani
• Keywords: Chrysosporium; Phanerochaete; TOR signaling; Pathogenic fungus

The Target Of Rapamycin (TOR) signaling pathway is known to regulate growth in response nutrient availability and stress eukaryotic cells. In the present study, we have investigated TOR white-rot fungus Phanerochaete chrysosporium. Inhibition of activity by rapamycin affects conidia germination hyphal highlighting conserved mechanism susceptibility rapamycin. Interestingly, secreted protein content also affected treatment. Finally, homologs components can be identified P. Altogether, those results indicate that chrysosporium plays a central role this fungus.