HIV-1 elite controllers present a high frequency of activated regulatory T and Th17 cells

• DOI: 10.1371/journal.pone.0228745
• Publication Date: 2020-02-05T13:37:30Z
• Authors: Diogo G. Caetano; Hury H. S. de Paula; Gonzalo Bello; Brenda Hoagland; Larissa M. Villela; Beatriz Grinsztejn; Valdilea G. Veloso; Mariza G. Morgado; Monick L. Guimarães; Fernanda H. Côrtes
• Keywords: Cart

HIV-1 infection is characterized by generalized deregulation of the immune system, resulting in increased chronic activation. However, some individuals called HIV controllers (HICs) present spontaneous control viral replication and have a more preserved system. Among HICs, discordant results been observed regarding activation frequency different T cell subsets, including Treg Th17 cells. We evaluated activation, differentiation regulatory profiles two groups HICs—elite (ECs) viremic (VCs)—and compared them to those cART-treated (cART) HIV-1-negative (HIV-neg) individuals. ECs demonstrated similar levels activated CD4+ CD8+ cells comparison HIV-neg, while cART VCs showed elevated subset analyses differences only for transitional memory between EC HIV-neg groups. VC higher frequencies terminally differentiated, naïve, stem lower central group. presented cells, differentiated HICs total also resting than Furthermore, we high Th17/Treg ratios both HIC Our data that had low which could restrict be indicative mucosal response these