Cardiovascular risk factors in HIV infected individuals: Comparison with general adult control population in Greece

• DOI: 10.1371/journal.pone.0230730
• Publication Date: 2020-03-30T17:23:47Z
• Authors: Giota Touloumi; Natasa Kalpourtzi; Vasileios Papasta...; Vasilios Paparizos; Georgios Adamis; Anastasia Antoniadou; Maria Chini; Argiro Karakosta; Konstantinos Makr...; Magda Gavana; Apostolos Vantarakis; Mina Psichogiou; Simeon Metallidis; Nikolaos V. Sipsas; Helen Sambatakou; Christos Hadjichr...; Paraskevi V. Voul...; George Chrysos; Charalambos Gogos; Grigoris Chlouver...; Grigoris Tripsianis; Yannis Alamanos; George Stergiou
• Keywords: Adult; Male; 2. Zero hunger; Adolescent; Greece; Science; Q; R; HIV Infections; Middle Aged; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Cardiovascular Diseases; Risk Factors; Case-Control Studies; Medicine; Humans; Female; Research Article; Aged

Background Although combined antiretroviral therapy has substantially improved the prognosis of people living with HIV (PLHIV), mortality remains higher compared to general population, mainly due prevalence non-HIV-related comorbidities, including cardiovascular diseases (CVD). We assessed CVD risk and its contributing factors in adult PLHIV versus population controls Greece. Settings Cross-sectional comparison (Athens-Multicenter-AIDS-Cohort-Study; AMACS) (National health examination survey; EMENO). Methods All HIV-infected adults ≥1 measurement interest (blood pressure, lipids, glucose, weight, height) between 2012–2014 all EMENO participants (2014–2016) were included. Ten-year total was estimated using Framingham (FRS) or Systematic Coronary Risk Evaluation (SCORE) equations. Results 5839 (median age:41.6 years, 85.4% males) 4820 age:48 48.4% Adjusting for age, sex origin, more likely be current smokers (adjusted OR:1.53 [95% CI:1.35–1.74]) dyslipidemic (aOR:1.18; [1.04–1.34]), less obese (aOR:0.44 [0.38–0.52], no differences hypertension, diabetes high (≥20%) FRS but greater odds (≥5%) SCORE (aOR:1.55 [1.05–2.30]). Further adjustment educational level, anti-HCV positivity BMI showed hypertension PLHIV. Conclusions Despite relative absence obesity, have traditional fatal population. Regular screening early management should priority prevention.