Reduced hippocampal volume in adolescents with psychotic experiences: A longitudinal population-based study

• DOI: 10.1371/journal.pone.0233670
• Publication Date: 2020-06-03T13:34:15Z
• Authors: Ana Calvo; Darren W. Roddy; Helen Coughlan; Ian Kelleher; Colm Healy; Michelle Harley; Mary Clarke; Alexander Leemans; Thomas Frodl; Erik O’Hanlon; Mary Cannon
• Keywords: Male; Adolescent; Science; General Biochemistry,Genetics and Molecular Biology; Psychotic Disorders/diagnostic imaging; Neuroimaging; diagnostic imaging [Psychotic Disorders]; Hippocampus; 03 medical and health sciences; 0302 clinical medicine; Journal Article; Humans; pathology [Psychotic Disorders]; ddc:610; Longitudinal Studies; General; Child; diagnostic imaging [Hippocampus]; Research Support, Non-U.S. Gov't; Q; R; Bullying; Organ Size; Magnetic Resonance Imaging; 3. Good health; pathology [Hippocampus]; Psychotic Disorders; Case-Control Studies; Medicine; Female; General Agricultural and Biological Sciences; Hippocampus/diagnostic imaging; Research Article; Follow-Up Studies

Aims Smaller hippocampal volumes are among the most consistently reported neuroimaging findings in schizophrenia. However, little is known about people who report psychotic experiences. This study investigated differences volume between young without formal diagnoses experiences (PEs) and those do not such also if any persisted over two years. Methods A nested case-control of 25 adolescents (mean age 13.5 years) with PEs matched controls 13.36 were drawn from a sample 100 local schoolchildren. High-resolution T1-weighted anatomical imaging subsequent automated cortical segmentation (Freesurfer 6.0) was undertaken to determine total volumes. Comprehensive semi-structured clinical interviews performed including information on PEs, mental early life stress (bullying). Participants invited for second scan at Results 19 completed both scans. Hippocampal bilaterally lower PE group compared moderate effects sizes baseline [left hippocampus p = 0.024 d 0.736, right 0.018, 0.738] 2 year follow up 0.027 0.702, 0.048 0.659] throughout. These survived adjustment co-morbid disorders stress. Conclusions Psychotic associated loss this appears be independent possible confounders as