Chronic kidney disease in cats alters response of the plasma metabolome and fecal microbiome to dietary fiber

• DOI: 10.1371/journal.pone.0235480
• Publication Date: 2020-07-02T17:34:04Z
• Authors: Jean A. Hall; Matthew I. Jackson; Dennis E. Jewell; Eden Ephraim
• Keywords: Pomace

The objectives were to determine the effects of feeding different fiber types healthy cats and with chronic kidney disease (CKD) on plasma metabolites fecal microbiome. Methods A cross-over study within a split-plot design was performed using (n = 10) CKD [IRIS Stage 1 2; n 10]. Cats fed dry Prescription Diet® k/d® Feline chicken, during pre-trial period then randomly assigned two treatments for 4 weeks each. Treatment foods formulated similar food, exception that they contained 0.500% betaine, 0.586% oat beta glucan, either 0.407% short chain fructooligosaccharides (scFOS) or 3.44% apple pomace. Both had crude percent (2.0 2.1% scFOS pomace, respectively) whereas soluble 0.8 1.6%, respectively. Results Plasma separated based health status. At baseline, significantly higher circulating concentrations creatinine, urea, some microbial host tryptophan including several indole sulfates kynurenate. Healthy antioxidant α-tocopherol after consuming pomace; alternatively, inflammatory sphingolipid scFOS, but not more oxidized glutathione pomace compared as well scFOS. After lower phenolic uremic toxins guaiacol sulfate 4-vinylphenol there five significant microbiota OTU differences in cats. Overall, OTUs resistant change source. Counts an unclassified genus family S24-7 order Bacteroidales (OTU 100296), at baseline (P 0.001), increased consumption food containing 0.006). Linear regression analysis showed this negative correlations toxins. None between changed consumed Conclusions Health status impacts influence dietary fermentable fibers feline metabolome readily fermented such is preferable source CKD.