Health-related quality of life of moderate and severe haemophilia patients: Results of the haemophilia-specific quality of life index in Korea

• DOI: 10.1371/journal.pone.0238686
• Publication Date: 2020-09-03T17:45:14Z
• Authors: Hee Jo Baek; Young Shil Park; Ki Young Yoo; Jin-Hye Cha; Young-Joo Kim; Kun Soo Lee
• Keywords: Cross-sectional study; Arthropathy

The assessment of health-related quality life (HRQoL) as a patient-reported outcome provides information about the patients' general well-being well effects disease and its treatment. This study aimed to investigate HRQoL using both generic haemophilia-specific QoL instruments assess clinical factors associated with among haemophilia patients in Korea. In this cross-sectional, multicenter, observational study, moderate-to-severe aged 8–64 years were recruited between November 2012 September 2013. EQ-5D Questionnaire, EQ Visual Analogue Scale, Haemophilia-Specific (Haemo-QoL) Questionnaire (Haemo-QoL for 8–16 Haemo-A-QoL ≥17 years) used HRQoL. A total 605 participants mean age 29.32 ± 12.62 enrolled. Haemo-QoL scores revealed significant differences by group (children vs. adolescent adult, 26.44 11.3 28.88 11.1 38.43 17.7, respectively, p < 0.001). "Sports leisure," "family planning," "view" adults "perceived support," "friends," "dealing" children adolescents identified domains greatest impairments. was significantly impaired following factors: hepatitis, haemophilia-induced disability, bleeding experiences within last 6 months, joint bleedings haemophilic arthropathy. According multivariate regression analysis, showed negative association presence disability (β = 0.222, 0.0001), months 0.098, 0.010), arthropathy 0.212, 0.0001). decreased older conditions These findings may provide insights into adequate management measurements.