Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients

• DOI: 10.1371/journal.pone.0239773
• Publication Date: 2020-10-08T17:53:33Z
• Authors: Yuji Shiga; Naohisa Hosomi; Tomohisa Nezu; Hiromi Nishi; Shiro Aoki; Masahiro Nakamori; Kenichi Ishikawa; Naoto Kinoshita; Eiji Imamura; Hiroki Ueno; Tomoaki Shintani; Hiroki Ohge; Hiroyuki Kawaguchi; Hidemi Kurihara; Shinichi Wakabayashi; Hirofumi Maruyama
• Keywords: Stroke; Antibody titer

Oral health conditions and cerebral small vessel disease, such as white matter lesions or microbleeds (CMBs), are associated with the incidence of stroke. The purpose this study was to examine associations between oral (serum IgG titers periodontal pathogens) presence severity CMBs in acute stroke patients. From January 2013 April 2016, patients were registered two hospitals. Serum samples evaluated for antibody against 9 pathogens using ELISA method. cut-off points reactivity (the positive decision point) each antigen defined more than a mean unit + 1 standard deviation (after logarithmic transformation) all subjects. on T2*-weighted MRI. In all, 639 (ischemic, n = 533 hemorrhagic, 106; 73.1 ± 12.9 years old). Among these patients, 627 available CMB evaluation. pathogens, only Campylobacter rectus (C. rectus) CMBs. prevalence serum C. higher among those without (14.6% vs. 8.7%, P 0.025). addition, remained one factors multivariate logistic analysis (odds ratio 2.03, 95% confidence interval 1.19–3.47, 0.010). A titer