Periodontal pathogens alter the synovial proteome. Periodontal pathogens do not exacerbate macroscopic arthritis but alter the synovial proteome in mice

• DOI: 10.1371/journal.pone.0242868
• Publication Date: 2020-12-31T19:05:29Z
• Authors: Anna-Lena Buschhart; Lennart Bolten; Johann Volzke; Katharina Ekat; Susanne Kneitz; Stefan Mikkat; Bernd Kreikemeyer; Brigitte Müller-H...
• Keywords: Aggregatibacter actinomycetemcomitans; Proteome; Inflammatory arthritis

Rheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory diseases that appear to occur in tandem. However, the mutual impact PD exerts on RA vice versa has not yet been defined. To address this issue, we set up an animal model analyzed how two prime inducers of periodontitis— Porphyromonas gingivalis (Pg) Aggregatibacter actinomycetemcomitans (Aa)– differ their pathogenic potential. Our experimental setup included collagen induced (CIA) mouse, oral inoculation with Pg or Aa induce alveolar bone loss combination both inverted orders events. Neither pathobiont impacted macroscopic did exacerbate loss. there were subtle differences between former inducing more if was before CIA. On a molecular level, led differential expression patterns synovial membranes reminiscent cellular humoral immune responses, respectively. The specific signatures proteomes suggest role for pathogens shaping disease subtypes setting stage subsequent therapy response.