Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study

• DOI: 10.1371/journal.pone.0243604
• Publication Date: 2020-12-15T19:11:22Z
• Authors: Thiago Domingos C...; Ricardo Luiz Cord...; João Carlos Campo...; Bruno Caldin da S...; Roseny dos Reis R...; Guilherme Martins...; Thais Dias Midega; Niklas Söderberg ...; Bárbara Vieira Ca...; Flávia Nunes Dias...; Hélio Penna Guima...; Gustavo Faissol J...; Valdir Fernandes ...; Leonardo José Rol...
• Keywords: 2019-20 coronavirus outbreak; Betacoronavirus; Coronavirus Infections; Pandemic

Coagulation abnormalities in COVID-19 patients have not been addressed depth.To perform a longitudinal evaluation of coagulation profile admitted to the ICU with COVID-19.Conventional tests, rotational thromboelastometry (ROTEM), platelet function, fibrinolysis, antithrombin, protein C and S were measured at days 0, 1, 3, 7 14. Based on median total maximum SOFA score, divided two groups: ≤ 10 > 10.Thirty studied. Some conventional as aPTT, PT INR remained unchanged during study period, while alterations others laboratory tests detected. Fibrinogen levels increased both groups. ROTEM clot firmness groups from Day 0 Moreover, ROTEM-FIBTEM was high groups, slight decrease day 14 group increase same period 10. Fibrinolysis low decreased over time all most pronounced observed INTEM lysis Also, D-dimer plasma higher than normal reference range free baseline time, Finally, had lower plasminogen Protein ​​than <10, which may represent less fibrinolysis activity state hypercoagulability.COVID-19 hypercoagulability state, characterized by impaired endogenous anticoagulation fibrinolysis. The magnitude seems correlate severity organ dysfunction. only detected but it much more complex, where changes fibrinolytic system.