Partial cortico-hippocampectomy in cats, as therapy for refractory temporal epilepsy: A descriptive cadaveric study

• DOI: 10.1371/journal.pone.0244892
• Publication Date: 2021-01-15T18:28:21Z
• Authors: Jessica Zilli; Monika Kressin; Anne Schänzer; Marian Kampschulte; Martin J. Schmidt
• Keywords: Hippocampal sclerosis; Anterior temporal lobectomy

Cats, similar to humans, are known be affected by hippocampal sclerosis (HS), potentially causing antiepileptic drug (AED) resistance. HS can occur as a consequence of chronic seizure activity, trauma, inflammation, or even primary disease. In temporal lobe resection is the standardized therapy in patients with refractory epilepsy (TLE). The majority TLE free after surgery. Therefore, purpose this prospective cadaveric study establish surgical technique for cats treatment AED resistant seizures. Ten different head morphology were examined. Pre-surgical magnetic resonance imaging (MRI) and computed tomography (CT) studies animals’ carried out complete 3D reconstruction head, brain, hippocampus. resected specimens brains histologically examined tissue injury adjacent feasibility procedure, well usability removed specimen histopathological examination, was assessed. Moreover, micro-CT (mCT) examination brain two additional performed order assess vasculature reason possible intraoperative complications. all but one, cortex hippocampus successful without any evidence traumatic vascular lesions surrounding neurovascular structures. one cat, presence mechanical damage (a fissure) thalamic surface evident histopathologic post-resection. All fields dentate gyrus identified via histological examination. describes new approach (partial cortico-hippocampectomy) offering potential clinical diagnostic which do not respond adequately medical therapy.