Regimen simplification and medication adherence: Fixed-dose versus loose-dose combination therapy for type 2 diabetes

• DOI: 10.1371/journal.pone.0250993
• Publication Date: 2021-05-04T20:15:57Z
• Authors: Anna-Katharina Böhm; Udo Schneider; Jens Aberle; Tom Stargardt
• Keywords: Fixed-dose combination; Pill; Regimen; Combination therapy; Medication Adherence; Pharmacotherapy

Suboptimal patient adherence to pharmacological therapy of type 2 diabetes may be due in part pill burden. One way reduce burden patients who need multiple medications is use fixed-dose combinations. Our study aimed compare the effects combination versus loose-dose on medication and persistence, health care utilization, therapeutic safety, morbidities, treatment modification with over three years.