Pathology, bacteriology and molecular studies on caseous lymphadenitis in Camelus dromedarius in the Emirate of Abu Dhabi, UAE, 2015-2020

• DOI: 10.1371/journal.pone.0252893
• Publication Date: 2021-06-08T17:54:39Z
• Authors: Abdelnasir Mohamm...; Ghada El Derdiri ...; Hassan Zackaria A...; Nasereldien Altai...; El Tigani Ahmed E...; Farouk Mohamed Ha...; Abdelmalik Ibrahi...; Asma Abdi Mohamed...; Salama Suhail Moh...
• Keywords: Corynebacterium pseudotuberculosis; Caseous lymphadenitis; Bacteriology; Corynebacterium

Caseous lymphadenitis (CLA) or pseudotuberculosis is a chronic zoonotic bacterial disease caused by Corynebacterium pseudotuberculosis, which affects livestock and humans. This study aimed to describe the pathology, bacteriology confirm identity of pathogen 16S rRNA gene sequencing in Camelus dromedarius. A total 12 camels with suspected CLA three regions Abu Dhabi Emirate (Abu Dhabi, Al Ain Dhafra), United Arab (UAE) were subjected clinical postmortem examinations from January 2015 December 2020. Clinically, emaciated showed presence external caseous abscesses suggestive CLA. Postmortem examination multiple variable sizes material encapsulated fibrous tissue liver, lungs, muscle, lymph nodes. Following examination, blood, pus different samples collected for subsequent analysis. Histopathological all organs stained Hematoxylin Eosin (H&E) indicated central caseo-necrotic core that was admixed colonies infiltration inflammatory cells, surrounded pyogenic membrane, an outer connective capsule. Bacterial culture identified isolates biotype ovis strain, these shown be sensitive antibiotics tested (penicillin, ampicillin, Co-trimoxazole, enrofloxacin tetracycline). Moreover, confirmed partial 100% pseudotuberculosis. Phylogenetic analysis based on sequence clearly differentiates other species Corynebacterium. Briefly, this provided basic information infection Camels will help controlling region.