Hyperbaric hyperoxemia as a risk factor for ventilator-acquired pneumonia?

• DOI: 10.1371/journal.pone.0253198
• Publication Date: 2021-06-23T17:42:44Z
• Authors: Morgan Caplan; Thibault Duburcq; Anne-Sophie Moreau; Julien Poissy; Saad Nseir; Erika Parmentier-...
• Keywords: Ventilator-associated Pneumonia; Univariate analysis; Tracheotomy; SAPS II; Medical record

Ventilator-acquired pneumonia (VAP) is the leading cause of serious associated infections in Intensive Care Units (ICU) and with significant morbidity. The use hyperbaric oxygen therapy (HBOT) patients on mechanical ventilation may increase exposure to certain risk factors such as hyperoxemia need for multiple transfers. aim our study was assess relationship between HBOT VAP.This retrospective observational performed from March 2017 2018 a 10-bed ICU using HBOT. All receiving (MV) more than 48 hours were eligible. VAP defined clinical radiological criteria. Data collection carried out via digital medical records. Risk determined by univariate multivariate analysis.Forty-two (23%) 182 enrolled developed at least one episode VAP. One hundred twenty-four (68%) received incidence rate 34 per 1000 ventilator days. occurrence significantly immunosuppression (p<0.029), MV duration (5 [3-7] vs 8 [5-11.5] days, p<0.0001), length stay (8 [5-13] 19.5 [13-32] reintubation (p<0.0001), intra-hospital transport (p = 0.001), paralytic agents 0.013), tracheotomy 0.003) prone position 0.003). not Multivariate analysis identified (OR: 8.3 [2.6-26.6]; 3.5 [1.3-9.2]; p 0.011) 3.3 [1.3-8.4]; 0.014) independent VAP.Known are be found within population. HBOT, however, an extra factor this group. Further experimental investigations needed understand impact physiological microbiome.