Variable effects of underlying diseases on the prognosis of patients with COVID-19

• DOI: 10.1371/journal.pone.0254258
• Publication Date: 2021-07-19T17:36:50Z
• Authors: Yong Jun Choi; Ju-Young Park; Hye Sun Lee; Jin Suh; Jeung Yoon Song; Min-Kwang Byun; Jae Hwa Cho; Hyung Jung Kim; Hye Jung Park
• Keywords: Adult; Adolescent; Science; 610; Comorbidity; Mortality / trends; Pulmonary Disease; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 0302 clinical medicine; Neoplasms; Chronic Obstructive / epidemiology*; 80 and over; Diabetes Mellitus; Humans; Mortality; Preschool; Child; COVID-19 / epidemiology*; Aged; Aged, 80 and over; Heart Failure; Kidney Diseases / epidemiology*; Q; Diabetes Mellitus / epidemiology*; Length of Stay / statistics & numerical data; R; COVID-19; Infant; Length of Stay; Middle Aged; Survival Analysis; 3. Good health; COVID-19 / mortality; Heart Failure / epidemiology*; Child, Preschool; Medicine; Kidney Diseases; Neoplasms / epidemiology*; Research Article

Underlying diseases might be risk factors for poor prognosis in patients with coronavirus disease (COVID-19); however, we still do not know whether these are independent affecting prognosis, which type of underlying factors, and clinical outcomes affected. We retrospectively reviewed cohort data from 7,590 de-identified COVID-19 who were diagnosed using severe acute respiratory syndrome-coronavirus-2 RNA polymerase chain reaction test up to May 15, 2020. used linked-medical claims provided by the Health Insurance Review Assessment Service South Korea. identified diagnostic codes patients’ files January 1, 2019 December 31, 2019. The total mortality rate was 3.0% COVID-19. After adjusting age, sex, concomitant chronic conditions, found that congestive heart failure, pulmonary diseases, diabetes without complications, renal malignancy significantly increased cost treatment. Cerebrovascular disease, paralysis significant prolonging hospital stay. Diabetes complications independently associated intensive care unit admission. In addition, failure (odds ratio [OR], 1.724; P = 0.003), dementia (OR, 1.598; 0.012), 1.821; 0.002 OR, 1.518; 0.022, respectively), 2.299; 0.002), 1.529; 0.039) death, even after adjustments. effects variable according outcome. Therefore, should monitored more closely because they at a prognosis.