Nasopharyngeal microbiome composition associated with Streptococcus pneumoniae colonization suggests a protective role of Corynebacterium in young children

• DOI: 10.1371/journal.pone.0257207
• Publication Date: 2021-09-16T17:30:41Z
• Authors: Lei Xu; Joshua Earl; Michael E. Pichic...
• Keywords: Corynebacterium

Streptococcus pneumoniae (Spn) is a leading respiratory tract pathogen that colonizes the nasopharynx (NP) through adhesion to epithelial cells and immune evasion. Spn actively interacts with other microbiota in NP but nature of these interactions are incompletely understood. Using 16S rRNA gene sequencing, we analyzed composition children or without colonization. 96 were included study cohort. 74 samples when 6 months old 85 12 old. We found several genera correlated negatively positively colonization, some correlations appeared be influenced by daycare attendance confounding factors such as upper infection (URI) Moraxella Among genera, Corynebacterium showed consistent inverse relationship colonization little influence factors. isolated propinquum C . pseudodiphtheriticum both inhibited growth serotype 22F strain vitro