COVID-19 in lung transplant recipients—Risk prediction and outcomes

• DOI: 10.1371/journal.pone.0257807
• Publication Date: 2021-10-06T20:51:32Z
• Authors: Jan C. Kamp; Jan B. Hinrichs; Jan Fuge; Raphael Ewen; Jens Gottlieb
• Keywords: DLCO; Univariate analysis; Risk of mortality

Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge optimal treatment, mortality, outcomes, and appropriate predictors is limited. A retrospective analysis was performed a German high-volume transplant center between 19 th March 2020 18 May 2021. Impact of physical psychological health, clinical mortality were analyzed including follow-up visits up to 12 weeks infection survivors. Predictive parameters survival assessed using univariate multivariate proportional hazards regression models. Out 1,046 patients follow-up, 31 acquired during the pandemic. (39%) died 26 (84%) hospitalized . In survivors significant decline exercise capacity (p = 0.034), TLC 0.02), DLCO 0.007) observed 3 months. Anxiety, depression, self-assessed quality life remained stable. Charlson comorbidity index predicted (HR 1.5, 1.1–2.2; p 0.023). recipients with pre-existing CLAD, inferior. However, CLAD did not predict mortality. remains disease recipients, particularly case comorbidities. Further studies long term impact needed.