SerumCovid database: Description and preliminary analysis of serological COVID-19 diagnosis in healthcare workers

• DOI: 10.1371/journal.pone.0265016
• Publication Date: 2022-03-17T18:20:37Z
• Authors: Isis Didier Lins; Leonardo Streck R...; Caio Bezerra Sout...; Felipe Cavalcanti...; Márcio José das C...; João Mateus Marqu...; Alexsandro dos Sa...; Marcelo Victor de...; Ramon Nascimento ...; Ewerton Henrique ...; José Cândido Ferraz; Alice Araújo; Mariana Fernandes; Ana Lisa Gomes
• Keywords: Adult; Male; Adolescent; Science; Health Personnel; Enzyme-Linked Immunosorbent Assay; Antibodies, Viral; COVID-19 Serological Testing; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Humans; SARS-CoV-2; Q; R; COVID-19; Middle Aged; Immunoglobulin A; 3. Good health; Databases as Topic; Immunoglobulin G; Medicine; Female; Brazil; Research Article

Serological databases represent an important source of information to perceive COVID-19 impact on health professionals involved in combating the disease. This paper describesSerumCovid, a COVID-19 serological database focused on the diagnosis of health professionals, providing a preliminary analysis to contribute to the understanding of the antibody response to the SARS-CoV-2. The study population comprises 321 samples from 236 healthcare and frontline workers fighting COVID-19 in Vitória de Santo Antão, Brazil. Samples were collected from at least six days of symptoms to more than 100 days. The used immunoenzymatic assays were Euroimmun Anti-SARS-CoV-2 ELISA IgG and IgA. The most common gender inSerumCovidis female, while the most common age group is between 30 and 39 years old. However, no statistical differences were observed in either genders or age categories. The most reported symptoms were fatigue, headaches, and myalgia. Still, some subjects presented positive results for IgA after 130 days. Based on a temporal analysis, we have not identified general patterns as subjects presented high and low values of IgA and IgG with different evolution trends. Unexpectedly, for subjects with both serological tests, the outcome of IgA and IgG tests were the same (either positive or negative) for more than 80% of the samples. Therefore,SerumCovidhelps better understand how COVID-19 affected healthcare and frontline workers, which increases knowledge about the infection and enables direct prevention actions.