Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study

• DOI: 10.1371/journal.pone.0272373
• Publication Date: 2022-08-01T18:59:02Z
• Authors: Ricardo Kenji Nawa; Ary Serpa Neto; Ana Carolina Lazarin; Ana Kelen da Silva; Camila Nascimento; Thais Dias Midega; Raquel Afonso Cas...; Thiago Domingos C...; Karina Tavares Ti...
• Keywords: Single Center; SOFA score

Severe coronavirus disease 2019 (COVID-19) patients frequently require mechanical ventilation (MV) and undergo prolonged periods of bed rest with restriction activities during the intensive care unit (ICU) stay. Our aim was to address degree mobilization in critically ill COVID-19 undergoing MV support.Retrospective single-center cohort study. We analyzed patients' mobility level, through Perme ICU Mobility Score (Perme Score) admitted ICU. The Index (PMI) calculated [PMI = ΔPerme (ICU discharge-ICU admission)/ICU length stay], were categorized as "improved" (PMI > 0) or "not improved" ≤ 0). Comparisons performed stratification according use support.From February 2020, 2021, 1,297 assessed for eligibility. Out those, 949 included study [524 (55.2%) classified 425 (44.8%) improved"], 396 (41.7%) received overall rate out able walk ≥ 30 meters at discharge were, respectively, 526 (63.3%) 170 (20.5%). After adjusting confounders, independent predictors improvement level frailty (OR: 0.52; 95% CI: 0.29-0.94; p 0.03); SAPS III 0.75; 0.57-0.99; 0.04); SOFA 0.58; 0.43-0.78; < 0.001); after first hour admission 0.41; 0.17-0.99; tracheostomy 0.54; 0.30-0.95; extracorporeal membrane oxygenation 0.21; 0.05-0.8; neuromuscular blockade 0.53; 0.3-0.95; a higher 0.35; 0.28-0.43; palliative 0.05; 0.01-0.16; longer stay 0.79; 0.61-0.97; 0.04) associated lower chance improvement, while non-invasive within 2.45; 1.59-3.81; 0.001) 2.25; 1.56-3.26; 0.001), respectively; vasopressor 2.39; 1.07-5.5; 0.03) improvement.The reduced status less than half patients.