The need for blood transfusion therapy is associated with increased mortality in children with traumatic brain injury

• DOI: 10.1371/journal.pone.0279709
• Publication Date: 2023-01-06T18:31:50Z
• Authors: Madhuradhar Chegondi; Jose F. Hernandez...; Fuad Alkhoury; Balagangadhar R. ...
• Keywords: Quartile

Blood transfusion therapy (BTT) is widely used in trauma patients. However, the adverse effects of BTT pediatric patients with traumatic brain injury (TBI) were poorly studied. The objective this study to evaluate effect on mortality children severe TBI.In retrospective cohort analysis, we analyzed 2012 and 2016 Kids' Inpatient Databases a weighted sample obtain national outcome estimates. We included aged 1 month 21 years TBI who mechanically ventilated, considered TBI; then compared demographics, comorbidities, rates those had undergone did not. Statistical analysis was performed using chi-squared test regression models. In addition, correlative propensity score matched cases 1:1 controls (non-BTT) based age, gender, hospital region, income quartiles, race, All Patients Refined Diagnosis Related Groups (APRDRG) severity illness scores minimize confounding variables between groups.Out 87,980 diagnosis TBI, 17,199 (19.5%) analysis. documented 3184 (18.5%) children. Among group, higher non-BTT group [31.6% (29.7-33.5%) vs. 14.4 (13.7-15.1%), (OR 2.2, 95% CI 1.9-2.6; p<0.05)]. infants adolescents, white APRDRG illness, cardiac arrest, platelet, coagulation factor transfusions associated mortality. propensity-matched risk (32.1% [30.1-34.2] 17.4% [15.8-19.1], p<0.05; OR: CI: 1.9-2.6).In blood