Morphometric characterization and temporal temperature measurements during hepatic microwave ablation in swine

• DOI: 10.1371/journal.pone.0289674
• Publication Date: 2023-08-04T17:23:06Z
• Authors: Nicole A. Varble; Ivane Bakhutashvili; Sheridan L. Reed; Jose Delgado; Zoi Tokoutsi; Bruno Frackowiak; Marco Baragona; John W. Karanian; Bradford J. Wood; William F. Pritchard
• Keywords: Microwave ablation; Ablation zone; Ex vivo

Heat-induced destruction of cancer cells via microwave ablation (MWA) is emerging as a viable treatment primary and metastatic liver cancer. Prediction the impacted zone where cell death occurs, especially in presence vasculature, challenging but may be achieved biophysical modeling. To advance characterize thermal MWA for focal treatment, an vivo method experimental dataset were created assessment models designed to dynamically predict parameters, given delivery device, power, location, proximity vessels.MWA size, shape, temperature characterized monitored absence perfusion ex tissue-mimicking thermochromic phantom (TMTCP) at two power settings. Temperature was over time using implanted thermocouples with their locations defined by CT. TMTCPs used identify location relative probe. In 6 swine, contrast-enhanced CTs additionally acquired visualize vasculature along corresponding post-mortem gross pathology.Bench studies demonstrated average sizes 4.13±1.56cm2 8.51±3.92cm2, solidity 0.96±0.06 0.99±0.01, ablations centered 3.75cm 3.5cm proximal probe tip, temperatures 50 ºC 14.5±13.4s 2.5±2.1s 40W 90W ablations, respectively. imaging showed volumes 9.8±4.8cm3 33.2±28.4cm3 3D 0.87±0.02 0.75±0.15, pathology hemorrhagic halo area 3.1±1.2cm2 9.1±3.0cm2 respectfully. Temperatures reached 50ºC 19.5±9.2s 13.0±8.3s respectively.MWA results are more variable than manufacturer-provided bench predictions due vascular stasis, heat-induced tissue changes, operating conditions. Accurate prediction zones requires comprehensive validation sets.