Probiotics attenuate valproate-induced liver steatosis and oxidative stress in mice

• DOI: 10.1371/journal.pone.0294363
• Publication Date: 2023-11-16T18:28:47Z
• Authors: Wenfang Song; Xinrui Yan; Yu Zhai; Jing Ren; Ting Wu; Han Guo; Yu Song; Xiaojiao Li; Yingjie Guo
• Keywords: Steatosis; Liver steatosis

Valproate (valproic acid, VPA), a drug for the treatment of epilepsy and bipolar disorder, causes liver steatosis with enhanced oxidative stress. Accumulating evidences exhibite that gut microbiota plays an important role in progression nonalcoholic fatty disease (NAFLD). However, whether contributes to VPA-caused hepatic needs be elucidated. A mixture five probiotics was selected investigate their effects on stress mice orally administered VPA 30 days. Probiotics significantly attenuated lipid accumulation VPA-treated via inhibiting expression cluster differentiation 36 (CD36) distinct diacylglycerol acyltransferase 2 (DGAT2). Meanwhile, exerted protective effect against VPA-induced by decreasing pro-oxidant cytochrome P450 2E1 (CYP2E1) level activating Nrf2/antioxidant enzyme pathway. Moreover, altered relative abundance at phylum, family genera levels, while partially restored these changes. Spearman's correlation analysis showed several specific were correlated stress-related indicators. These results suggest exert health benefits abrogation manipulating microbial homeostasis.