Polymorphisms in the glucagon-like peptide-1 receptor gene and their interactions on the risk of osteoporosis in postmenopausal Chinese women

• DOI: 10.1371/journal.pone.0295451
• Publication Date: 2023-12-14T18:27:11Z
• Authors: Chang Liu; Xiaoxue Bao; Yawei Tian; Peng Xue; Yan Wang; Yukun Li
• Keywords: SNP

Postmenopausal osteoporosis (PMOP) is a prevalent form of primary osteoporosis, affecting over 40% postmenopausal women. Previous studies have suggested potential association between single nucleotide polymorphisms (SNPs) in glucagon-like peptide-1 receptor (GLP-1R) and PMOP Chinese However, available evidence remains inconclusive. Therefore, this study aimed to investigate the possible GLP-1R SNPs Han Thus, we conducted case-control with 152 women aged 45-80 years, including 76 without osteoporosis. Seven were obtained from National Center Biotechnology Information Genome Variation Server. We employed three genetic models assess variants women, while also investigating SNP-SNP SNP-environment interactions risk PMOP. In study, selected seven (rs1042044, rs2268641, rs10305492, rs6923761, rs1126476, rs2268657, rs2295006). Of these, minor allele A rs1042044 was significantly associated an increased Genetic model analysis revealed that individuals carrying had higher developing dominant (P = 0.029, OR 2.76, 95%CI: 1.09-6.99). Furthermore, multiplicative interaction found rs2268641 (Pinteraction 0.034). Importantly, remained independent age, menopausal duration, family history body mass index. no significant relationship observed haplotypes conclusion, suggests close on augmented by rs2268641. These results provide new scientific insights into development personalized prevention strategies treatment approaches for