Short term effect of antimicrobial photodynamic therapy and probiotic L. salivarius WB21 on halitosis: A controlled and randomized clinical trial

• DOI: 10.1371/journal.pone.0297351
• Publication Date: 2024-07-02T19:04:09Z
• Authors: Pamella de Barros...; Marcela Leticia L...; Juliana Maria Alt...; Ana Paula Taboada...; Lara Jansiski Motta; Marcia Pinto Alve...; Dione Kawamoto; David Casimiro de...; Elaine Marcílio S...; Kristianne Porta ...; Raquel Agnelli Me...; Alessandro Melo D...; Anna Carolina Rat...; Sandra Kalil Buss...
• Keywords: Treponema denticola; Tannerella forsythia; Lactobacillus salivarius

Objective This study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) and use probiotics on treatment halitosis. Methods Fifty-two participants, aged from 18 25 years, exhaling sulfhydride (H 2 S) ≥ 112 ppb were selected. They allocated into 4 groups (n = 13): Group 1: tongue scraper; 2: treated once with aPDT; 3: probiotic capsule containing Lactobacillus salivarius WB21 (6.7 x 10 8 CFU) xylitol (280mg), 3 times a day after meals, for 14 days; 4: aPDT days. Halimetry gas chromatography (clinical evaluation) microbiological samples collected dorsum before aPDT, as well 7, 14, 30 The clinical data failed follow normal distribution; therefore, comparisons made using Kruskal-Wallis test (independent measures) Friedman ANOVA (dependent followed by appropriate posthoc tests, when necessary. For data, seeing distribution, rank sum was performed Dunn’s post-test. significance level α 0.05. Results Clinical results (halimetry) showed an immediate significant reduction in halitosis (p 0.0008) and/or scraper 0.0006). Probiotics no difference relation initial levels 0.7530). No differences found control appointments. amount Porphyromonas gingivalis , Tannerella forsythia Treponema denticola not altered throughout analysis 0.1616, p 0.2829 0.2882, respectively). Conclusion There scraping, but there number bacteria study, or times, both results. New trials are necessary better assess tested therapies. Trial registration Trials NCT03996044 .