The causal relationship between gut microbiota and immune skin diseases: A bidirectional Mendelian randomization

• DOI: 10.1371/journal.pone.0298443
• Publication Date: 2024-03-21T17:45:38Z
• Authors: Fei Feng; Ruicheng Li; Rui Tian; Xueyi Wu; Nannan Zhang; Zhenhua Nie
• Keywords: Mendelian Randomization

Background Increasing evidence suggests that alterations in gut microbiota are associated with a variety of skin diseases. However, whether this association reflects causal relationship remains unknown. We aimed to reveal the between and diseases, including psoriasis, atopic dermatitis, acne, lichen planus. Methods obtained full genetic summary data for microbiota, planus from public databases used three methods, mainly inverse variance weighting, analyze relationships these diseases using bidirectional Mendelian randomization, as well sensitivity stability analysis results multiple methods. Results The showed there were five genera psoriasis group, seven dermatitis total ten acne four group. corrected false discovery rate Eubacteriumfissicatenagroup (P = 2.20E-04, OR 1.24, 95%CI:1.11–1.40) still relationship. In contrast, reverse randomization results, was no an microbiota. Conclusion demonstrated immune provide new therapeutic perspective study diseases: targeted modulation dysregulation specific bacterial taxa prevent treat