Increased serum levels of IL-40 are associated with IgA and NETosis biomarkers in Covid-19 patients: IL-40 and infectious diseases

• DOI: 10.1371/journal.pone.0321578
• Publication Date: 2025-05-02T17:23:46Z
• Authors: Umit Bagriacik; Resul Karakus; Melek Yaman; Nihan Oruklu; Milat Araz; Zafer Kalayci; Hasan Selcuk Ozger; Yesim Yildiz; Esin Senol
• Keywords: Nephelometry

Interleukin 40 (IL-40) is a novel cytokine that has been associated with B lymphocytes, particularly IgA-secreting cells in gut mucosa. Considering mucosal association of IL-40, we aimed to determine serum IL-40 levels patients Covid-19. We compared concentrations healthy people both mild symptoms SARS-CoV-2 infection and pneumonia. was measured by ELISA. Serum IgA were tested nephelometry. For the first time, demonstrated increased significantly. The elevation related severity infection. Therefore, quite higher Our findings indicated NETosis biomarkers increase. Based on these findings, speculated would be immune activities mucosa lungs SARS-CoV-2-infected patients. This may linked mechanism control NETosis.