In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells

• DOI: 10.1371/journal.ppat.1000748
• Publication Date: 2010-01-28T22:43:58Z
• Authors: Joseph K. Wong; Matthew C. Strain; Rodin Porrata; Elizabeth Reay; Sumathi Sankaran-...; Caroline C. Ignacio; Theresa Russell; Satish K. Pillai; David J. Looney; Satya Dandekar
• Keywords: Simian immunodeficiency virus; CTL*; Viremia

The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamics during antiretroviral treatment simian immunodeficiency virus (SIV) infected rhesus macaques following depletion test the importance cytotoxic effects in clearance cells productively with SIV. As previously described, plasma load (VL) increased was proportional magnitude GALT, confirming direct relationship between loss replication. Surprisingly, first phase decay administration drugs not slower depleted animals compared controls indicating that short lifespan average cell reflection T-lymphocyte (CTL) killing. Our findings support dominant role for non-cytotoxic T-cells on suggest effects, if present, are limited early, pre-productive stages life cycle. These observations have important implications future strategies augment immune HIV.