Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses

0301 basic medicine Aging Receptors, Antigen, T-Cell, alpha-beta 3207 Medical Microbiology Inbred Strains 32 Biomedical and Clinical Sciences Herpesvirus 1, Human CD8-Positive T-Lymphocytes Mice Models Receptors Vaccinia 2.1 Biological and endogenous factors Listeriosis anzsrc-for: 1107 Immunology Biology (General) anzsrc-for: 3204 Immunology Pediatric alpha-beta Vaccines Recombinant Virulence 3 Good Health and Well Being anzsrc-for: 3107 Microbiology Specific Pathogen-Free Organisms 3. Good health 3204 Immunology Infectious Diseases Immunological Antigen Human Research Article anzsrc-for: 1108 Medical Microbiology 570 QH301-705.5 1.1 Normal biological development and functioning DNA, Recombinant 610 Mice, Inbred Strains Vaccinia virus Vaccines, Attenuated Vaccine Related 03 medical and health sciences anzsrc-for: 32 Biomedical and Clinical Sciences Biodefense Animals anzsrc-for: 3207 Medical Microbiology Herpesvirus 1 Inflammatory and immune system Immunologic Deficiency Syndromes Models, Immunological Herpes Simplex DNA RC581-607 Newborn T-Cell Listeria monocytogenes Emerging Infectious Diseases Attenuated anzsrc-for: 0605 Microbiology Animals, Newborn Immune System Immunization Immunologic diseases. Allergy Immunologic Memory
DOI: 10.1371/journal.ppat.1003572 Publication Date: 2013-09-12T21:06:09Z
ABSTRACT
Microbial infection during various stages of human development produces widely different clinical outcomes, yet the links between age-related changes in immune compartment and functional immunity remain unclear. The ability system to respond specific antigens mediate protection early life is closely correlated with level diversification lymphocyte antigen receptors. We have previously shown that neonatal primary CD8+ T cell response replication competent virus significantly constricted compared adult response. In present study, we analyzed subsequent formation memory cells their secondary infectious challenge. particular, asked whether less diverse clonotypes are elicited by vaccination 'locked-in' cell, thus may compromise strength immunity. Here report poor recall responses adults comprised a repertoire lower avidity cells. During later challenge compete poorly fully naïve outgrown This has important implications for timing life.
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