Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses
0301 basic medicine
Aging
Receptors, Antigen, T-Cell, alpha-beta
3207 Medical Microbiology
Inbred Strains
32 Biomedical and Clinical Sciences
Herpesvirus 1, Human
CD8-Positive T-Lymphocytes
Mice
Models
Receptors
Vaccinia
2.1 Biological and endogenous factors
Listeriosis
anzsrc-for: 1107 Immunology
Biology (General)
anzsrc-for: 3204 Immunology
Pediatric
alpha-beta
Vaccines
Recombinant
Virulence
3 Good Health and Well Being
anzsrc-for: 3107 Microbiology
Specific Pathogen-Free Organisms
3. Good health
3204 Immunology
Infectious Diseases
Immunological
Antigen
Human
Research Article
anzsrc-for: 1108 Medical Microbiology
570
QH301-705.5
1.1 Normal biological development and functioning
DNA, Recombinant
610
Mice, Inbred Strains
Vaccinia virus
Vaccines, Attenuated
Vaccine Related
03 medical and health sciences
anzsrc-for: 32 Biomedical and Clinical Sciences
Biodefense
Animals
anzsrc-for: 3207 Medical Microbiology
Herpesvirus 1
Inflammatory and immune system
Immunologic Deficiency Syndromes
Models, Immunological
Herpes Simplex
DNA
RC581-607
Newborn
T-Cell
Listeria monocytogenes
Emerging Infectious Diseases
Attenuated
anzsrc-for: 0605 Microbiology
Animals, Newborn
Immune System
Immunization
Immunologic diseases. Allergy
Immunologic Memory
DOI:
10.1371/journal.ppat.1003572
Publication Date:
2013-09-12T21:06:09Z
AUTHORS (8)
ABSTRACT
Microbial infection during various stages of human development produces widely different clinical outcomes, yet the links between age-related changes in immune compartment and functional immunity remain unclear. The ability system to respond specific antigens mediate protection early life is closely correlated with level diversification lymphocyte antigen receptors. We have previously shown that neonatal primary CD8+ T cell response replication competent virus significantly constricted compared adult response. In present study, we analyzed subsequent formation memory cells their secondary infectious challenge. particular, asked whether less diverse clonotypes are elicited by vaccination 'locked-in' cell, thus may compromise strength immunity. Here report poor recall responses adults comprised a repertoire lower avidity cells. During later challenge compete poorly fully naïve outgrown This has important implications for timing life.
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CITATIONS (28)
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