Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses

• DOI: 10.1371/journal.ppat.1003572
• Publication Date: 2013-09-12T21:06:09Z
• Authors: Brian D. Rudd; Vanessa Venturi; Norah L. Smith; Kito Nzingha; Emily L. Goldberg; Gang Li; Janko Nikolich-Zu...; Miles P. Davenport
• Keywords: 0301 basic medicine; Aging; Receptors, Antigen, T-Cell, alpha-beta; 3207 Medical Microbiology; Inbred Strains; 32 Biomedical and Clinical Sciences; Herpesvirus 1, Human; CD8-Positive T-Lymphocytes; Mice; Models; Receptors; Vaccinia; 2.1 Biological and endogenous factors; Listeriosis; anzsrc-for: 1107 Immunology; Biology (General); anzsrc-for: 3204 Immunology; Pediatric; alpha-beta; Vaccines; Recombinant; Virulence; 3 Good Health and Well Being; anzsrc-for: 3107 Microbiology; Specific Pathogen-Free Organisms; 3. Good health; 3204 Immunology; Infectious Diseases; Immunological; Antigen; Human; Research Article; anzsrc-for: 1108 Medical Microbiology; 570; QH301-705.5; 1.1 Normal biological development and functioning; DNA, Recombinant; 610; Mice, Inbred Strains; Vaccinia virus; Vaccines, Attenuated; Vaccine Related; 03 medical and health sciences; anzsrc-for: 32 Biomedical and Clinical Sciences; Biodefense; Animals; anzsrc-for: 3207 Medical Microbiology; Herpesvirus 1; Inflammatory and immune system; Immunologic Deficiency Syndromes; Models, Immunological; Herpes Simplex; DNA; RC581-607; Newborn; T-Cell; Listeria monocytogenes; Emerging Infectious Diseases; Attenuated; anzsrc-for: 0605 Microbiology; Animals, Newborn; Immune System; Immunization; Immunologic diseases. Allergy; Immunologic Memory

Microbial infection during various stages of human development produces widely different clinical outcomes, yet the links between age-related changes in immune compartment and functional immunity remain unclear. The ability system to respond specific antigens mediate protection early life is closely correlated with level diversification lymphocyte antigen receptors. We have previously shown that neonatal primary CD8+ T cell response replication competent virus significantly constricted compared adult response. In present study, we analyzed subsequent formation memory cells their secondary infectious challenge. particular, asked whether less diverse clonotypes are elicited by vaccination 'locked-in' cell, thus may compromise strength immunity. Here report poor recall responses adults comprised a repertoire lower avidity cells. During later challenge compete poorly fully naïve outgrown This has important implications for timing life.