IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells

• DOI: 10.1371/journal.ppat.1004635
• Publication Date: 2015-02-06T17:11:50Z
• Authors: Hyang-Mi Lee; Anne Fleige; Ruth Forman; Sunglim Cho; Aly Azeem Khan; Ling-Li Lin; Duc T. Nguyen; Aisling O'Hara-Hall; Zhinan Yin; Christopher A. Hu...; Werner Muller; Li-Fan Lu
• Keywords: Regulatory T cell

IFNγ signaling drives dendritic cells (DCs) to promote type I T cell (Th1) immunity. Here, we show that activation of DCs by is equally crucial for the differentiation a population T-bet+ regulatory (Treg) specialized inhibit Th1 immune responses. Conditional deletion receptor in but not Treg resulted severe defect this specific subset, leading exacerbated pathology during parasitic infections. Mechanistically, IFNγ-unresponsive failed produce sufficient amount IL-27, cytokine required optimal T-bet induction cells. Thus, signalling endows with ability efficiently control immunity through promoting corresponding population.