γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)

• DOI: 10.1371/journal.ppat.1004702
• Publication Date: 2015-03-06T18:57:02Z
• Authors: Camille Khairallah; Sonia Netzer; Arnaud Villacreces; Marina Juzan; Benoît Rousseau; Sara Dulanto; Alban Giese; Pierre Costet; Vincent Praloran; Jean-François Moreau; Pierre Dubus; David Vermijlen; Julie Déchanet-Me...; Myriam Capone
• Keywords: Adoptive Cell Transfer

Cytomegalovirus (CMV) is a leading infectious cause of morbidity in immune-compromised patients. γδ T cells have been involved the response to CMV but their role protection has not firmly established and dependency on other lymphocytes addressed. Using C57BL/6 αβ and/or cell-deficient mice, we here show that are as competent protect mice from CMV-induced death. cell-mediated control viral load prevented organ damage. cell recovery by bone marrow transplant or adoptive transfer experiments rescued CD3ε−/− death confirming protective antiviral cells. As observed humans, different subsets were induced upon challenge, which differentiated into effector memory This was liver lungs implicated both CD27+ CD27− NK largely preponderant producers IFNγ cytotoxic granules throughout infection, suggesting did principally rely either these two functions. Finally, strikingly sufficient fully Rag−/−γc−/− death, demonstrating they can act absence B Altogether our results uncover an autonomous function cells, open new perspectives for characterization non classical mode action should foster design based therapies, especially useful compromised