CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

• DOI: 10.1371/journal.ppat.1005177
• Publication Date: 2015-10-20T18:28:18Z
• Authors: Prakash K. Gupta; Jernej Godec; David Wolski; Emily Adland; Kathleen Yates; Kristen E. Pauken; Cormac Cosgrove; Carola Ledderose; Wolfgang G. Junger; Simon C. Robson; E. John Wherry; Galit Alter; Philip J. R. Goulder; Paul Klenerman; Arlene H. Sharpe; Georg M. Lauer; W. Nicholas Haining
• Keywords: Chronic infection

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying potentially reversing cell exhaustion. Herein, we show the ectonucleotidse CD39 a marker exhausted CD8+ cells. specific HCV or HIV high levels CD39, but those EBV CMV do not. expressed by in infection enzymatically active, co-expressed with PD-1, marks transcriptional signature correlates load HCV. In mouse model Lymphocytic Choriomeningitis Virus infection, virus-specific contain population CD39high absent functional memory elicited acute This enriched phenotypic profile terminal These findings provide new exhaustion, implicate purinergic pathway regulation