Dietary zinc and the control of Streptococcus pneumoniae infection
Lung Diseases
570
572
QH301-705.5
Immunology
2405 Parasitology
Microbiology
Pneumococcal Infections
Mice
03 medical and health sciences
1311 Genetics
Virology
Genetics
1312 Molecular Biology
Animals
Biology (General)
Molecular Biology
2403 Immunology
0303 health sciences
Virulence
Animal
2404 Microbiology
600
RC581-607
3. Good health
Disease Models, Animal
Zinc
Streptococcus pneumoniae
Disease Models
Dietary Supplements
2406 Virology
Parasitology
Female
Immunologic diseases. Allergy
Research Article
DOI:
10.1371/journal.ppat.1007957
Publication Date:
2019-08-22T17:25:52Z
AUTHORS (21)
ABSTRACT
Human zinc deficiency increases susceptibility to bacterial infection. Although supplementation therapies can reduce the impact of disease, molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause pneumonia, which prevalent in regions deficiency. We report that dietary levels dictate outcome S. infection murine model. Dietary restriction impacts tissue with distribution post-infection altered, and virulence enhanced. activation infiltration phagocytic cells was not affected by restriction, their efficacy control compromised. shown be highly sensitive intoxication, this process impaired restricted mice isolated cells. Collectively, these data show how sensitivity while revealing role as component host antimicrobial defences.
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