Dietary zinc and the control of Streptococcus pneumoniae infection

Lung Diseases 570 572 QH301-705.5 Immunology 2405 Parasitology Microbiology Pneumococcal Infections Mice 03 medical and health sciences 1311 Genetics Virology Genetics 1312 Molecular Biology Animals Biology (General) Molecular Biology 2403 Immunology 0303 health sciences Virulence Animal 2404 Microbiology 600 RC581-607 3. Good health Disease Models, Animal Zinc Streptococcus pneumoniae Disease Models Dietary Supplements 2406 Virology Parasitology Female Immunologic diseases. Allergy Research Article
DOI: 10.1371/journal.ppat.1007957 Publication Date: 2019-08-22T17:25:52Z
ABSTRACT
Human zinc deficiency increases susceptibility to bacterial infection. Although supplementation therapies can reduce the impact of disease, molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause pneumonia, which prevalent in regions deficiency. We report that dietary levels dictate outcome S. infection murine model. Dietary restriction impacts tissue with distribution post-infection altered, and virulence enhanced. activation infiltration phagocytic cells was not affected by restriction, their efficacy control compromised. shown be highly sensitive intoxication, this process impaired restricted mice isolated cells. Collectively, these data show how sensitivity while revealing role as component host antimicrobial defences.
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