Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice

• DOI: 10.1371/journal.ppat.1010067
• Publication Date: 2021-11-16T18:35:27Z
• Authors: Denise Silva Nogu...; Luciana Maria de ...; Chiara Cássia Oli...; Ana Clara Gazzine...; Fernando Sérgio B...; Fabrício Marcus S...; Lucas Kraemer; Matheus Mattos; Mariana Santos Ca...; Nathália Maria Re...; Marianna de Carva...; Deborah Aparecida...; Ana Maria Caetano...; Marcelo Vidigal C...; Lilian Lacerda Bueno; Soraya Gaze; Remo Castro Russo; Pedro Henrique Ga...; Ricardo Toshio Fu...
• Keywords: Ascaris suum; Ascaris

Human ascariasis is the most prevalent but neglected tropical disease in world, affecting approximately 450 million people. The initial phase of Ascaris infection marked by larval migration from host's organs, causing mechanical injuries followed an intense local inflammatory response, which characterized mainly neutrophil and eosinophil infiltration, especially lungs. During pulmonary phase, lesions induced excessive immune responses contribute to tissue remodeling fibrosis lung dysfunction. In this study, we investigated relationship between SIgA levels eosinophils. We found that TLR2 TLR4 signaling induces eosinophils promotes production during suum infection. Therefore, control parasite burden involves influx subsequent promotion levels. addition, also demonstrate participate process after injury caused migration, contributing dysfunction re-infected mice. conclusion, postulate play a central role mediating host innate humoral controlling burden, inflammation, Furthermore, suggest use probiotics can induce eosinophilia morbidity helminthic diseases with cycles.