Unique cellular immune signatures of multisystem inflammatory syndrome in children

• DOI: 10.1371/journal.ppat.1010915
• Publication Date: 2022-11-02T17:43:22Z
• Authors: Anuradha Rajamani...; Pavan Kumar Nathella; Aishwarya Venkata...; Poovazhagi Varada...; Srinithi Kannan; Arul Nancy Pandia...; Rachel Mariam Renji; Elayarani Elavarasan; Akshith Thimmaiah; Kandasamy Sasidaran; Nedunchelian Kris...; Suresh Natarajan; Ganesh Ramaswamy; Balasubramanian S...; Sulochana Putlibai; Syed Hissar; Elilarasi Selladurai; K. Ranganathan Um...; Thomas B. Nutman; Subash Babu
• Keywords: Plasmacytoid dendritic cell

The clinical presentation of MIS-C overlaps with other infectious/non-infectious diseases such as acute COVID-19, Kawasaki disease, dengue, enteric fever, and systemic lupus erythematosus. We examined the ex-vivo cellular parameters aim distinguishing from syndromes overlapping presentations. children differed non-MIS-C conditions by having increased numbers naïve CD8 + T cells, naïve, immature atypical memory B cells diminished transitional memory, stem cell central effector CD4 classical, activated plasma monocyte (intermediate non-classical) dendritic (plasmacytoid myeloid) subsets. All above alterations were significantly reversed at 6–9 months post-recovery in MIS-C. Thus, is characterized a distinct signature that distinguishes it Trial Registration: ClinicalTrials.gov clinicaltrial.gov. No: NCT04844242 .