The intriguing phenomenon of cross-kingdom infections of plant and insect viruses to fungi: Can other animal viruses also cross-infect fungi?

• DOI: 10.1371/journal.ppat.1011726
• Publication Date: 2023-10-26T17:22:43Z
• Authors: Ida Bagus Andika; Xinran Cao; Hideki Kondo; Liying Sun
• Keywords: 0301 basic medicine; Opinion; QH301-705.5; Fungi; Insect Viruses; RC581-607; Plants; Viroids; 3. Good health; Plant Viruses; 03 medical and health sciences; Animals; Humans; Immunologic diseases. Allergy; Biology (General); Plant Diseases

Fungi are highly widespread and commonly colonize multicellular organisms that live in natural environments. Notably, studies on viruses infecting plant-associated fungi have revealed the interesting phenomenon of the cross-kingdom transmission of viruses and viroids from plants to fungi. This implies that fungi, in addition to absorbing water, nutrients, and other molecules from the host, can acquire intracellular parasites that reside in the host. These findings further suggest that fungi can serve as suitable alternative hosts for certain plant viruses and viroids. Given the frequent coinfection of fungi and viruses in humans/animals, the question of whether fungi can also acquire animal viruses and serve as their hosts is very intriguing. In fact, the transmission of viruses from insects to fungi has been observed. Furthermore, the common release of animal viruses into the extracellular space (viral shedding) could potentially facilitate their acquisition by fungi. Investigations of the cross-infection of animal viruses in fungi may provide new insights into the epidemiology of viral diseases in humans and animals.