Modulation of host lipid metabolism by virus infection leads to exoskeleton damage in shrimp

• DOI: 10.1371/journal.ppat.1012228
• Publication Date: 2024-05-13T17:42:44Z
• Authors: Xin-Xin Wang; Ming-Jie Ding; Jie Gao; Ling Zhao; Rong Cao; Xian-Wei Wang
• Keywords: White spot syndrome; Arthropod; Lipogenesis

The arthropod exoskeleton provides protection and support is vital for survival adaption. integrity mechanical properties of the are often impaired after pathogenic infection; however, detailed mechanism by which infection affects remains largely unknown. Here, we report that damage to shrimp caused modulation host lipid profiles with white spot syndrome virus (WSSV). WSSV disrupts performance inducing expression a chitinase (Chi2) in sub-cuticle epidermis decreasing cuticle chitin content. induction Chi2 mediated nuclear receptor can be activated certain enriched long-chain saturated fatty acids infection. exoskeleton, an aftereffect lipogenesis WSSV, significantly impairs motor ability shrimp. Blocking WSSV-caused restored improved infected Therefore, this study reveals modulates internal metabolism resulting phenotypic impairment, new insights into interactions between virus.