A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation

• DOI: 10.1371/journal.ppat.1012882
• Publication Date: 2025-01-22T18:42:46Z
• Authors: Wenjia Yu; Meng Li; Wenjun Wang; Haiyan Zhuang; Jiamin Luo; Yuying Sang; Cecile Segonzac; Alberto P. Macho
• Keywords: Ralstonia solanacearum

Gram-negative bacterial pathogens inject effector proteins inside plant cells using a type III secretion system. These effectors manipulate cellular functions and suppress the immune system in order to promote proliferation. Despite fact that are exogenous threatening potentially exposed protein degradation systems cells, relative stable able perform their virulence functions. In this work, we found RipE1, an secreted by wilt pathogen, Ralstonia solanacearum , undergoes phosphorylation of specific residues promotes its stability. Moreover, RipE1 associates with ubiquitin proteases, which contribute deubiquitination stabilization. The absence those sites or host proteases leads substantial decrease accumulation, indicating hijacks post-translational modification regulators own results suggest stability constitute another molecular event subject co-evolution between plants pathogens.