CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth

• DOI: 10.1371/journal.ppat.1012916
• Publication Date: 2025-01-31T18:48:10Z
• Authors: Gina L. Griffith; Kawthar Machmach; Ningbo Jian; Dohoon Kim; Margaret C. Costanzo; Matthew Creegan; Isabella Swafford; Gautam Kundu; Lauren Yum; Jessica S. Bolton; Lauren Smith; Bonnie M. Slike; Elke S. Bergmann-...; Rasmi Thomas; Nelson L. Michael; Julie A. Ake; Leigh Anne Eller; Merlin L. Robb; Samantha M. Townsley; Shelly J. Krebs; Dominic Paquin-Pr...
• Keywords: CD16

New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute infection (AHI) in participants previously for neutralization breadth development. found significant differences γδ surface marker expression that developed compared to those did not. Activation of cells occurred within the first weeks acquisition associated with viral load. Expression CD16 Vδ1 CD57 Vδ2 were be significantly higher broad neutralizers AHI, development years later. In addition, levels was production founder virus Env-specific IgM. Thus, may promote breadth, which has implications strategies.