Prior TB, Smoking, and Airflow Obstruction

• DOI: 10.1378/chest.09-1435
• Publication Date: 2009-10-10T01:21:39Z
• Authors: Kin-bong Hubert Lam; Chao Qiang Jiang; Rachel E. Jordan; Martin R. Miller; Wei Sen Zhang; Kar Keung Cheng; Tai Hing Lam; Peymané Adab
• Keywords: Male; Time Factors; Thoracic; 610; 03 medical and health sciences; Smoking - Adverse Effects - Epidemiology; 0302 clinical medicine; Tuberculosis, Pulmonary - Complications - Epidemiology; Risk Factors; Confidence Intervals; Odds Ratio; Prevalence; Tuberculosis; Pulmonary - Complications - Epidemiology; Humans; Tuberculosis, Pulmonary; Smoking; Middle Aged; Prognosis; 3. Good health; Radiography; Airway Obstruction; Hong Kong - Epidemiology; Cross-Sectional Studies; Spirometry; Hong Kong; Female; Radiography, Thoracic; Airway Obstruction - Diagnosis - Epidemiology - Etiology; Follow-Up Studies

Prior pulmonary TB has been shown to be associated with a higher risk of airflow obstruction, which is the hallmark of COPD, but whether smoking modifies this relationship is unclear. We investigated the relationships between prior TB, smoking, and airflow obstruction in a Chinese population sample.Participants in the Guangzhou Biobank Cohort Study underwent spirometry, chest radiography, and a structured interview on lifestyle and exposures. Prior TB was defined as the presence of radiologic evidence suggestive of inactive TB. Airflow obstruction was based on spirometric criteria.The prevalence of prior TB in this sample (N = 8,066, mean age: 61.9 years) was 24.2%. After controlling for sex, age, and smoking exposure, prior TB remained independently associated with an increased risk of airflow obstruction (odds ratio = 1.37; 95% CI, 1.13-1.67). Further adjustment for exposure to passive smoking, biomass fuel, and dust did not alter the relationship. Smoking did not modify the relationship between prior TB and airflow obstruction.Prior TB is an independent risk factor for airflow obstruction, which may partly explain the higher prevalence of COPD in China. Clinicians should be aware of this long-term risk in individuals with prior TB, irrespective of smoking status, particularly in patients from countries with a high TB burden.