Effects of aqueous crude leaf extract of senecio biafrae on the histology of the frontal cortex, kidney, liver and testis of male sprague dawley rats

• DOI: 10.14196/sjbs.v1i1.68
• Publication Date: 2012-07-21
• Authors: A. O. Muhammed; D.A. Adekomi; Ahmad Tijani
• Keywords: Histology

Whenever any plant and/or herb is ingested, the body system interacts with it in an attempt to get rid of harmful toxins such may contain, especially if cannot convert foreign substance into useful components. This study was evaluate effects oral consumption aqueous leaf extract Senecio biafrae on histology frontal cortex, kidney, liver and testis Sprague Dawley rats as a marker toxicity. Twenty adult male weighing between 100-158 g were used (4-6 weeks old). They divided 2 groups. The treatment group A received 300 mg/kg weight S. for thirty days (30d). Histological observation liver, kidney testes revealed no significant abnormal alterations. control B equal volume phosphate buffered saline (PBS) also 30d histopathological abnormalities seen rats. Aqueous has deleterious histological profile