A comparative histological study on the effect of exposure to the smoke leaf extract of tobacco nicotiana, cannabis sativa and datura stramonium on the lungs of sprague-dawley rats

• DOI: 10.14196/sjms.v1i2.69
• Publication Date: 2012-08-31
• Authors: Adedayo D. Adekomi; Ahmad Tijani; Adam Moyosore Afodun; K.K. Quadri
• Keywords: Datura stramonium; Datura

Smoking may exert compromising effects on several organ systems of the body, but those in lungs are most deleterious. Therefore aim present study was to investigate some inhalation smoke extract Tobacco nicotiana (Tobacco), Cannabis sativa and Datura stramonium ( Jimson Weed ) respiratory system, especially lungs. Twenty male Sprague Dawley rats were divided into four groups A-D. The control group (A) not subjected any extracts, while B, C, D exposed from a completely burnt 0.74g leaf nicotiana, each for 5 minutes three times daily (7am, 10am, 1pm) respectively . duration exposure all five days. All sacrificed by decapitation lung tissues obtained animal using thoracotomy, blotted dry fixed buffered neutral formalin histopathological analysis Hematoxylin Eosin (H&E) stain. In tissue (A), histological profile preserved, whereas outline revealed disruptive characteristics such as emphysema, evidence bronchopneumonial features fibrosis, occlusion bronchi, dilation alveoli sac. conclusion, has integrity extension cause irreversible functional morphological alterations tissue.