Honeybee product therapeutic as stem cells homing for ovary failure

• DOI: 10.14202/vetworld.2016.1324-1330
• Publication Date: 2016-11-29T02:55:52Z
• Authors: Erma Safitri; Thomas V. Widiyatno; R. Heru Prasetyo
• Keywords: Homing (biology)

Aim: Complexity of the method isolation, cultivation in vitro and expensive cost transplantation process stem cells, it would require an innovation to homing differentiation cells increase folliculogenesis.The was achieved through provision food or beverages derived from natural materials like honeybee product.Through product, there will be accompany with sources body itself take place regeneration ovary. Materials Methods:Female rats model degenerative ovary obtained fasting but still have drinking water for 5 days.It caused malnutrition damage ovarian tissue.The administration 50% product (T1) performed 10 consecutive days, while positive control group (T0+) fasted not given negative (T0-) without product.Observations were taken raised folliculogenesis, tissue using routine H&E staining.Results: Homing shown vascular endothelial growth factor granulocyte colony-stimulating expression; enhancement folliculogenesis indicated by follicle dee Graaf count; factor-9 intact growing follicles. Conclusion:Honeybee can induced endogenous failure due malnutrition.