Hematologic changes and splenic index on malaria mice models given Syzygium cumini extract as an adjuvant therapy

• DOI: 10.14202/vetworld.2019.106-111
• Publication Date: 2019-01-21T12:37:41Z
• Authors: Lilik Maslachah; Rahmi Sugihartuti; Retno Sri Wahyuni
• Keywords: Syzygium; Plasmodium berghei

Aim: This research aimed to determine the efficacy of Syzygium cumini L. as an adjuvant therapy on blood changes and splenic index mice model malaria. Materials Methods: Mice were infected intraperitoneally with 0.2 ml red cell (RBC) that contains 1×106 Plasmodium berghei. 35 divided into seven treatment groups: Group K0: not infected; K1: K2: given chloroquine; P1: S. leaf extract; P2: chloroquine also P3: was stem bark P4: extract. Treatment for 4 days 24 h post-P. berghei infection. 21st day infection, taken from heart hematological examination, spleen examine measure weight length spleen. Hematological data analyzed by analysis variance test, if there is a difference, test continued Duncan's multiple range 5% level. Results: The K0 group has normal hemoglobin (HGB), RBC, hematocrit (HCT) significantly different (p<0.05) than other groups. HGB, HCT K1 under range, lowest, Mean corpuscular volume mean HGB values K2 groups showed decrease. number leukocytes, lymphocytes, monocytes increasing group. length, width, weight, width spleens K1. Conclusion: combination extract may increase amount erythrocyte; decrease monocytes; malaria models.