The differences in the number of fibroblasts and blood vessels after the topical and systemic administration of Lactobacillus casei Shirota probiotics for the treatment of traumatic ulcers in Wistar rats (Rattus norvegicus)

• DOI: 10.14202/vetworld.2021.1279-1283
• Publication Date: 2021-05-23T05:17:17Z
• Authors: Tuti Kusumaningsih; Anis Irmawati; Diah Savitri Erna...; Chiquita Prahasanti; Mohammed Aljunaid; Sarah Amelia
• Keywords: Lactobacillus casei; Systemic administration

Background and Aim: The use of drugs as a therapy for traumatic ulcers may lead to drug resistance other side effects. Lactobacillus casei Shirota can affect the number fibroblasts blood vessels in wound healing. aim this study was investigate difference fibroblast cells after topical systemic administration L. probiotics Wistar rats with ulcer. Materials Methods: Overall, 36 healthy male aged 2-3 months old weighing 175-250 g body weight were used sample. Traumatic ulcer made on labial fornix incisive inferior. subject divided into groups: (1) A control group over 3 days, (2) that distilled water 7 (3) underwent treatment (4) administered topically (5) (6) took oral days. observed through hematoxylin-eosin examination. Results: Based results study, significant (p=0.00) (p=0.018) 3-day compared 7-day (p=0.00). Conclusion: differences undergoing probiotics.