Treatment with Gaoziban Tablet Ameliorates Depression by Promoting GSK-3β Phosphorylation to Enhance the Wnt/β-catenin Activation in the Hippocampus of Rats

• DOI: 10.14218/jerp.2021.00016
• Publication Date: 2021-09-09T02:23:31Z
• Authors: Xin-Shuang Zou; Hai-Long Yin; Lei Shi; Hai-Ping Li; Meng-Heng Wang; Wan-Ci Song; Yang Luo; Wei-Liang Chen; He-Zhen Wu; Yan-Fang Yang; Jun-Feng Zan; Yan-Wen Liu; Han-Xiong Dan; Qiang Yin; Peng-Tao You
• Keywords: Depression

Background and objectivesDepression is a severe recurrent mental disease contributes to the global burden. However, there are limited effective treatments for depression. This study evaluated effect of compound Gaoziban tablet (CGZBT) on depression explored its potential mechanisms that underlie action in rats.