Gut dysbiosis as a risk factor of neonatal sepsis among preterm infants

• DOI: 10.14238/pi65.2.2025.96-102
• Publication Date: 2025-05-26T04:37:59Z
• Authors: Putri Maharani Tr...; Hardya Gustada Hi...; Rinawati Rohsiswatmo; Maya Yulindhini; Agus Firmansyah
• Keywords: Dysbiosis; Neonatal Sepsis

Background Preterm infants are at high risk of developing sepsis. An imbalance between the normal gut and pathogenic microbiomes, known as dysbiosis, has been proposed a condition that leads to neonatal Objective To assess for an association dysbiosis Methods A prospective cohort study was conducted involving very preterm or low birth weight admitted Neonatal Unit, Cipto Mangunkusumo Hospital, Jakarta, from November 2019 January 2021. The primary outcome proven and/or clinical independent variable defined ratio normal-to-pathogenic microbiome <1.0. Gut analysis performed using polymerase chain reaction test fecal specimen. Multivariate multiple logistic regression with adjustments potential confounders. Results Forty-three were recruited during period, median gestational age 30 (range 25-36) weeks 1,170 630-1855) grams. Among them, 28 (65.1%) had 25 (58.2%) developed incidence sepsis higher among (20 infants; 71.4%) than those without (5 33.3%). Dysbiosis hemodynamically significant patent ductus arteriosus increased sepsis, aOR 6.93 (95%CI 1.04 46.14; P=0.045) 22.7 1.45 355.29; P=0.026), respectively, after adjusting sex, birthweight, maternal infant morbidities, well vitamin D status. Conclusion is factor Maintaining balance essential first day life.