Common Variable Immunodeficiency with Several Gastrointestinal Manifestations

• DOI: 10.14309/crj.2017.106
• Publication Date: 2017-08-31T17:43:55Z
• Authors: Catarina Atalaia-...; Sandra Barbeiro; Pedro Marcos; Isabel Cotrim; Helena Vasconcelos
• Keywords: Common Variable Immunodeficiency; Villous atrophy; Hypogammaglobulinemia

Common variable immunodeficiency (CVID) is an disorder with a high incidence of gastrointestinal (GI) manifestations and increased risk gastric malignancy. We report case CVID mild anemia presenting multiple GI manifestations: low-grade dysplasia (LGD), enteropathy villous atrophy, refractory Giardia infection, nodular lymphoid hyperplasia, inflammatory bowel-like disease. The differential diagnosis celiac sprue could be challenging because flattening. Gastric LGD in patient for malignancy makes the appropriate surveillance cancer challenging.